Linkage disequilibrium due to random genetic drift
نویسندگان
چکیده
منابع مشابه
Linkage disequilibrium at steady state determined by random genetic drift and recurrent mutation.
order to understand the genetic architecture of Mendelian populations, we '2ave to know, in addition to gene frequencies, the degree of linkage disequilibrium between loci, namely, the extent to which combinations of genes at linked loci deviate from randomness. In panmictic populations, two factors are mainly responsible for the production of linkage disequilibrium. They are epistatic interact...
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In finite populations subject to selection, genetic drift generates negative linkage disequilibrium, on average, even if selection acts independently (i.e., multiplicatively) upon all loci. Negative disequilibrium reduces the variance in fitness and hence, by Fisher's (1930) fundamental theorem, slows the rate of increase in mean fitness. Modifiers that increase recombination eliminate the nega...
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Linkage disequilibrium (LD) is bases of genomic selection, genomic marker imputation, marker assisted selection (MAS), quantitative trait loci (QTL) mapping, parentage testing and whole genome association studies. The Particular alleles at closed loci have a tendency to be co-inherited. In linked loci this pattern leads to association between alleles in population which is known as LD. Two metr...
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ژورنال
عنوان ژورنال: Genetical Research
سال: 1969
ISSN: 0016-6723,1469-5073
DOI: 10.1017/s001667230000272x